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KMID : 0191120120270050560
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Journal of Korean Medical Science
2012 Volume.27 No. 5 p.560 ~ p.564
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A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hurthle Cell Thyroid Cancer and Meningioma
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Kim You-Lim
Jang Young-Woo
Kim Jin-Taek
Sung Su-Ah
Lee Tae-Seok
Lee Won-Mi
Kim Hyo-Jeong
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Abstract
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Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.
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KEYWORD
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Hyperparathyroidism, Primary Hyperaldosteronism, Thyroid Cancer, Hurthle-cell, Meningioma
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